COVID-19 and the Brain: Understanding the Lingering Psychological and Cognitive Impact

As the world moves forward from the acute crisis of COVID-19, many continue to grapple with its hidden aftermath—brain fog, memory issues, anxiety, and fatigue. This post explores the neuropsychological effects of Long COVID across all ages, shedding light on how the virus has altered cognitive health and mental well-being—and what evidence-based strategies can support recovery.

Luis Efren Aguilar, Psy.D.

red white and black textile
red white and black textile

COVID-19 reshaped the global health landscape—but its neurological and psychological consequences are still being understood. Even for those who recovered physically, the aftermath often includes anxiety, depression, and cognitive issues such as brain fog, memory lapses, and reduced attention span.

Long COVID and Neuropsychology

The National Institutes of Health has identified "Long COVID" as a condition that includes ongoing neurological symptoms such as:

  • Brain fog

  • Fatigue

  • Word-finding difficulty

  • Sensory disturbances


These may stem from neuroinflammation, microvascular damage, or persistent immune responses.

Mental Health Fallout

Isolation, grief, job loss, and collective uncertainty fueled a surge in:

  • Generalized anxiety disorder

  • Depression and suicidal ideation

  • Trauma responses (e.g., from ICU stays or sudden loss)


Children and Adolescents

Developmental delays, increased screen time, and reduced socialization have impacted children’s attention, emotional regulation, and learning capacities.

Cognitive Rehabilitation Approaches

  • Mental stamina training and pacing strategies

  • Cognitive-behavioral therapy for anxiety and mood symptoms

  • Mindfulness and fatigue management


Resources: